Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Graphical representation of KAT2A in licensing the epigenetic and metabolic reprogramming of inflammatory macrophages. In synovial tissues of RA patients, the increased expression of KAT2A promotes the inducible transcription of Il1b and Nlrp3 genes by catalyzing H3K9ac and limiting NRF2 activity, thereby leading to uncontrolled IL‐1β production and inflammatory injury in RA progression.
