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. 2023 May 25;11:1213114. doi: 10.3389/fcell.2023.1213114

FIGURE 2.

FIGURE 2

Comparison of ubiquitin, SUMO and NEDD8 conjugation pathways controlling NK cell-mediated recognition of tumor cells. (A) Schematic representation of the ubiquitin pathway and the ubiquitin-like protein modifications SUMOylation and Neddylation. Ub, ubiquitin; S, SUMO; N8, NEDD8. (B) Model depicting how ubiquitin, SUMO and NEDD8 pathways regulate CD16, NKG2D and DNAM-1 surface expression on NK cells (left) and NKG2D and DNAM-1 ligand expression on cancer cell (right). Therapeutic interventional strategies aimed to prevent post-translational mechanisms affecting expression of NK cell receptors and their cognate ligands on cancer cells are also shown.