Table 4.

List of toxicological studies with the NF

Reference	Type of study	Test system	Dose
Unpublished Study No. AG200051	Bacterial reverse mutation test (GLP, OECD TG 471 (1997))	Salmonella Typhimurium TA98, TA100, TA1535, TA1537 and E. coli WP2 uvrA	Up to 5,000 μg 6′‐SL/plate (absence and presence of S9 mix)
Unpublished Study No. 200059	Micronucleus study in bone marrow cells of mice (GLP, OECD TG 474 (2016))	Slc:ICR(ICR) mice	500, 1,000 and 2,000 mg 6′‐SL/kg bw
Unpublished Study No. CG220004	In vitro micronucleus study in cultured mammalian cells (GLP, OECD TG 487 (2016))	CHL/IU cells	500, 1,000 and 2,000 μg 6′‐SL/mL (absence and presence of S9 mix)
Unpublished Study No. 100603RG	90‐day repeated dose oral toxicity study in rats (GLP, OECD TG 408 (2018))	SD rats	542, 1,084 and 2,168 mg 6′‐SL/kg bw/day