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. 2023 Jun 12;13:9516. doi: 10.1038/s41598-023-36144-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of blood immune cell metrics with acute respiratory infections (ARI) in LoewenKIDS subcohort. (A) T cell receptor (TCR) repertoire clonality, richness and two diversity measures are shown for the LoewenKIDS subcohort in relation to ARI in the 1st year of life. (B) TCR repertoire clonality, richness and two diversity measures are shown for the LoewenKIDS subcohort in relation to ARI in the 2nd to 4th year of life. (C) B cell receptor (BCR) repertoire clonality, richness, two diversity measures and somatic hypermutation (SHM) are shown for the LoewenKIDS subcohort in relation to ARI in the 1st year of life. (D) BCR repertoire clonality, richness, two diversity measures and SHM are shown for the LoewenKIDS subcohort in relation to ARI in the 2nd to 4th year of life. Only subjects with > 80% of days covered in the symptom diary were included in the analyses (89 subjects for the analysis of year 1 and 65 subjects for the analysis of clonality as well as 66 subjects for the analysis of the other immune metrics in year 2–4). One-way ANOVA was used as statistical test and squared Pearson correlation coefficients R² are shown. Analyses and data plotting were performed using RStudio (version 1.1.456) and the tcR, ade4 and tidyverse packages.