. 2023 May 30;93(3):1181–1193. doi: 10.3233/JAD-230167

Table 2.

Wilcox-Test results for pairwise comparisons between all study groups, unadjusted for multiple comparison and adjusted for multiple comparisons (Benjamini & Hochberg)

Vitreous	Control	Versus AD		Versus		Versus		AD only	Versus AD+CTE		Versus AD+CTE		CTE only	Versus AD+CTE		AD + CTE
Biomarker		only		CTE		AD+CTE
	Median	p	p ^#	p	p ^#	p	p ^#	Median	p	p ^#	p	p ^#	Median	p	p ^#	Median
	(IQR)							(IQR)					(IQR)			(IQR)
tTau, pg/mL	167000	0.054^*	0.08^*	0.04^**	0.08^*	0.82	0.98	1720000	>0.99	>0.99	0.016^**	0.049^**	2170000	0.015^**	0.049^**	194000
	(84400–1010000)							(1030000–4190000)					(27900–6780000)			(57700–710000)
	n = 8							n = 7					n = 15			n = 9
pTau₁₈₁, U/mL	102 (55–256)	0.09^*	0.28	0.056^*	0.28	0.96	0.96	364 (284–446)	0.49	0.59	0.46	0.59	273 (175–435)	0.31	0.59	120 (39.6–410)
	n = 8							n = 7					n = 15			n = 9
pTau₂₃₁, U/mL	2510 (836–9480)	0.28	0.42	0.17	0.33	0.48	0.58	23000 (5610–29000)	0.97	0.97	0.04^**	0.13	17800 (1840–36400)	0.04^**	0.13	1180 (198–5190)
	n = 8							n = 7					n = 14			n = 9
Aβ₄₀, pg/mL	484 (363–700)	0.61	0.74	0.15	0.71	0.54	0.74	482 (382–546)	0.24	0.71	0.84	0.84	358 (176–482)	0.52	0.74	458 (245–563)
	n = 8							n = 7					n = 15			n = 9
Aβ₄₂, pg/mL	29.6 (21.6–43)	0.54	0.64	0.10	0.60	0.32	0.64	30.0 (20.5–31.8)	0.24	0.64	>0.99	>0.99	18.1 (6.02–25.7)	0.48	0.64	30.2 (10.1–33.1)
	n = 8							n = 7					n = 15			n = 9
NfL, pg/mL	811 (577–9700)	0.53	0.96	0.80	0.96	0.52	0.96	2640 (1050–2650)	0.96	0.96	0.65	0.96	1730 (714–4750)	0.34	0.96	1130 (99.6–3480)
	n = 7							n = 5					n = 14			n = 6
Eotaxin-1, pg/mL	49.8 (39.5–92.1)	0.96	>0.99	0.87	>0.99	0.09^*	0.28	66.5 (20.9–115)	>0.99	>0.99	0.07^*	0.28	54.1 (22.4–162)	0.14	0.28	19.5 (13.5–46.4)
	n = 8							n = 7					n = 14			n = 9

p, unadjusted p value; p^#, p value after adjusting for multiple comparisons testing. ^*p < 0.10; ^**p < 0.05. IQR, interquartile range; AD, Alzheimer’s disease; CTE, chronic traumatic encephalopathy; Aβ, amyloid-β; tTau, total tau; pTau, phosphorylated tau; NfL, neurofilament; pg/mL, picograms per milliliter; U/mL, units per milliliter.