. 2023 May 24;14(6):788–793. doi: 10.1021/acsmedchemlett.3c00079

Table 1. IC₅₀ Values of Na_V1.7 Inhibitors 1^a.

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	X	Y	hNa_V1.7 IC₅₀ (μM)	mNa_V1.7 IC₅₀ (μM)
I			0.052	1.7
1a	Ph	H	>10	>10
1b	CH₂Ph	H	>10	>10
1c	H	Ph	>10	>10
1d	Ph	Me	0.33	2.7
1e	Me	Ph	>10	>10

Data were obtained with a high-throughput electrophysiology system (IonWorks Quattro). Values are from a single experiment run in quadruplicate.

Table 1. IC50 Values of NaV1.7 Inhibitors 1a.