Table 5. Pharmacokinetic Parameters of Compound 36 in Rats^a.

	route and dose
	iv 1 mg/kg	po, 10 mg/kg
Tmax (h)		0.5
Cmax (ng/mL)	4627 ± 304	8243 ± 370
AUC0–t (h·ng/mL)	3375 ± 477	25672 ± 5668
AUC0–∞ (h·ng/mL)	3416 ± 495	25707 ± 5682
T1/2 (h)	1.4 ± 0.3	2.7 ± 0.2
Cl (mL/min/kg)	4.95 ± 0.77
Vdss (L/kg)	0.41 ± 0.04
F (%)		76.1

^aSprague–Dawley, n = 3.