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. 2023 May 19;14(6):827–832. doi: 10.1021/acsmedchemlett.3c00126

Table 1. ERα Binding Affinity (Kd) of ER(apt)D1, LCL-ER(apt)D1, VH-ER(apt)D1, POM-ER(apt)D1, and POM-Scr(apt)D1a.

entry compound Kd (nM)
1 ER(apt)D1-FAM 7.8 ± 0.6
2 LCL-ER(apt)D1-FAM 36.4 ± 0.6
3 VH-ER(apt)D1-FAM 21.2 ± 3.2
4 POM-ER(apt)D1-FAM 10.4 ± 2.5
5 POM-Scr(apt)D1-FAM >400
a

Data represent the mean ± SD (n = 3).