Table 1. Optimization of the Reaction Conditions^a.

entry	carrot cultivar	additive	time (h)	conv (%)b	yield, erc
1	orange	–	96	46	–
2	yellow	–	96	38	–
3	purple	–	96	66	–
4d	purple	TPGS-750-M	96	35	–
5d	purple	Triton X-100	96	18	–
6e	purple	buffer pH 6.0, 6.5, 7.0, 7.5	96	16, 31, 30, 41	–
7e	purple	buffer pH 8.0, 8.5, 9.0, 9.5	96	53, 90, 87, 85	–
8	purple	buffer pH 8.5	48	62	–
9f	purple	buffer pH 8.5	48	87	78%, >99:1

^aGeneral conditions: 14 (50 mg), water (35 mL), EtOH (1 mL), precut carrots (5 g), in Erlenmeyer flask, rt, stirred at 250 rpm.

^bConversion was determined by LCMS under 254 nm wavelength.

^cEnantiomeric ratio was determined by chiral SFC.

^d2 wt% of additive (0.7 g) was used.

^e20 mM of 1 M buffer solution (0.7 mL) was applied.

^fPurple carrots (10 g), isolated yield.