Table 3.

Direct and indirect effect (mediated by VA) of glycemic variability on in hospital death

	Full association, OR (95% CI)	Direct association, OR (95% CI)	Mediated by VA, OR (95% CI)	Percent mediation, %	P value for indirect effect
Crude	1.76 (1.64–1.89)	1.72 (1.60–1.84)	1.03 (1.02–1.03)	4.41	< 0.001
Adjusted	1.30 (120 − 1.41)	1.29 (1.12–1.40)	1.01 (1.01–1.02)	3.85	< 0.001

Adjusted for age, sex, ICU category, race, sepsis, myocardial infarction, heart failure, cerebrovascular disease, chronic pulmonary disease, malignant cancer, eGFR, serum sodium, potassium, mean arterial pressure, hear rate and average blood glucose