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. 2023 Jun 12;11:92. doi: 10.1186/s40478-023-01583-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Complement inhibition improves histological and cognitive outcomes. A Brain lesion volume at day 28 after TBI in PBS vs CR2-Crry treated groups measured using MRI. B Barnes maze performance in week 3 after TBI in PBS vs CR2-Crry treated groups. C Performance on the retention day of the Barnes maze showing individual data points. Data are shown as mean ± SEM. N = 9 per group. Tissue samples were taken from 6 randomly chosen animals for the CyTOF analysis. Significance was calculated in A using unpaired t-test and in B-C using 1-way Anova with Bonferroni post-test (*p < 0.05, ***p < 0.001)