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. 2023 Jun 12;11:92. doi: 10.1186/s40478-023-01583-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Complement inhibition affects the abundance of brain resident immune cells and the expression of functional receptors on infiltrating cells in the injured hemisphere. A Number of immune cells per experimental group and sample as identified by the expression of CD45 in the CyTOF panel. Data was acquired from ~ 62,000 cells from the injured hemisphere. The number of immune cells shown is normalized by the total number of isolated cells (see methods). B Summary of the change in percentage and the fold change in cell count of each immune cell type at days 3, 7 and 28 after TBI compared to the sham group. Non-significant changes are in gray. C MDS plot summarizing the differences in functional receptor expression among all 42 samples. The circle size is proportional to the number of immune cells in the sample. D, E Summary of all the significant changes in the expression of functional receptors by immune cell types D and percentage of functional clusters E upon treatment with CR2-Crry. Data are shown as mean and color-coded for statistical significance in panels B, D and E. N = 6 per group. *p < 0.05. Bonferroni correction was used for multiple comparisons in panel A. False discovery rate was used to adjust the p-value in the other panels. Abbreviations: cDC = conventional dendritic cell, pDC = plasmacytoid dendritic cell, MdC = monocyte-derived cell