Table 2.
Bivariate analysis and multivariable logistic regression analysis examining the associations with the composite outcome of Day 1–7 severe persistent acute kidney injury, Day 1–7 kidney replacement therapy use, and/or 28-day mortality
| Variable | Bivariate analysis | Multivariable logistic regression | |||
|---|---|---|---|---|---|
| Composite outcome | No composite outcome | p-value | Adjusted odds ratio (95% CI) | p-value | |
| N (%) cohort | 27 (38) | 45 (62) | – | – | – |
| Age, years | 6.1 (2.5, 20.2) | 14 (4.8, 17.2) | 0.45 | – | – |
| Sex, male (%) | 10 (37) | 17 (38) | 0.95 | – | – |
| PRISM III | 13 (9, 19) | 10.4 (8, 13.5) | 0.071* | 1.09 (0.98–1.2) | 0.11 |
| D1 VIS | 25 (10, 44) | 10 (2, 23.5) | 0.004* | 1.03 (0.99–1.07) | 0.10 |
| D1 ACE Level, ng/ml | 149 (70, 177) | 96 (78, 126) | 0.019* | 1.01 (1.02–1.03) | 0.025 |
| D1 ACE activity (U/L) | |||||
| Undetectable, n (%) | 23 (85) | 27 (60) | 0.025* | 6.6 (1.2–36.1) | 0.031 |
| D1 Renin + Prorenin, pg/ml | 16,774 (3484, 28,016) | 3037 (1231, 5111) | < 0.001* | 1.0 (1.0–1.0) | 0.07 |
Continuous data reported as median (IQR)
PRISM III Pediatric Risk of Mortality Score III, D day, VIS vasoactive-inotrope score, ACE angiotensin-converting enzyme
*Variables with alpha level < 0.15 on bivariate analysis were included in the
multivariate logistic regression model