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. Author manuscript; available in PMC: 2023 Jun 12.
Published in final edited form as: Sci Transl Med. 2023 May 3;15(694):eadg5562. doi: 10.1126/scitranslmed.adg5562

Fig. 2. Greater abundance of BSI species in case stools before infection onset despite no gross alpha diversity differences.

Fig. 2.

(A) Shannon diversity and (B) species richness displayed within 5-day windows (bins) relative to BSI. Values are averaged within 5-day windows for infants who produced more than one stool within the same 5-day span. (C) Mean relative abundance of BSI-causing species from each case in the 14 days before BSI versus the same species in controls. Mean value for each case species plotted versus abundance of same BSI-causing species in controls in the same DOL range. (D) PCoA of Bray-Curtis dissimilarity is shown by BSI-causing family. Number in parenthesis is percentage of variance explained. (E) Repeated-measures PERMANOVA results for variance contributed and Benjamini-Hochberg–corrected q value. Boxplots represent 25th to 75th median quartile, with horizontal black bar at the median. (A and B) LME model with participant as a random effect. (C) Wilcoxon signed-rank test. *P < 0.05. HM, human milk; DPI, days post infection.