TABLE 3.

Summary of Additional Benefits Using the Clinical SPCCT Prototype (Philips Healthcare) Compared With EID-CT in Human Clinical Research

Images	Organ	Application	Additional Outcomes	Reference
Ultra-high-resolution images	Heart	Coronary artery lumen	Improvement of diagnostic quality by a factor of 2	14
			Improvement of diagnostic confidence for half of the cases	14
		Coronary artery stent	Improvement of stent lumen and structure visualization	14,21 Figure 7
			Reduction of blooming artifacts and intraluminal artifacts	14,21 Figure 7
		Coronary artery plaque	Improvement of diagnostic quality by a factor of 2	14
			Improvement of diagnostic confidence for half of the cases	14
		Calcium scoring	More accurate quantification of the calcium volume	22
	Lung	Distal airways	Clearer visualization up to 5th level	13 Figure 6
		Distal vessels	Improvement of their sharpness and conspicuity	13
		Nodule	Improvement of detectability by a factor of 2	13,23
			Improvement of accuracy quantification	24
			Improvement of characterization	13,24
Low- and ultra-low-dose images	Chest	Nodule imaging	Improvement of the nodule sharpness and conspicuity	13
	Heart	Calcium scoring	Higher accuracy for low dose condition	25
Virtual monochromatic images	Heart	Coronary artery lumen	Improvement of diagnostic quality of distal lumen	14,26
	Aorta	Vascular imaging	Improvement of lumen opacification	14
	Pulmonary arteries	Vascular lung disease	Improvement of lumen opacification	Figure 11
	Carotid vessels	Carotid lumen	Improvement of lumen opacification	27
Iodine images	Carotid vessels	Carotid lumen	Specific visualization of the lumen	27
	Chest	Lung perfusion	Specific visualization of the lung microangiography	Figure 12
	Heart	Myocardial perfusion	Specific visualization of the myocardial perfusion	Figure 12

SPCCT indicates spectral photon-counting computed tomography; EID-CT, computed tomography equipped with energy-integrating detectors.