Table 5.2.

GRADE certainty ratings and their interpretation symbols^a

⊕⊕⊕⊕ High: We are very confident that the true effect lies close to that of the estimate of the effect.

⊕⊕⊕○ Moderate: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.

⊕⊕○○ Low: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.

⊕○○○ Very low: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

^a From the GRADE Handbook¹⁹².