Table 2.
An Overview of Studies Characteristics and Patients Demographics
| Study | Study period | Study design | Single/ multi-center | Sample size | Sex (M, F) | Ethnicity (n, %) | Adult (>18 years) and/or pediatric (n, %) | Mean age at diagnosis ± SD (range) | Mean age at follow-up/interview (SD, range) | Mean time since diagnosis ± SD (range) |
|---|---|---|---|---|---|---|---|---|---|---|
| Turner et al. 32 | Jan 2003- Sep 2007 | Retrospective | Single-center | 60 | 26 (43.3%), 34 (56.7%) | White (51, 85.0%), black/ African American (4, 6.67%), Hispanic (3, 5.0%), other (2, 3.33%) | Pediatric | 6.8 y (0.1-19.0) | 16.3 y (5.8-34.2) | 8.4 y (3.9 - 20.4) |
| Brinkman et al. 33 | Jan 2003- Sep 2007 | Retrospective | Single-center | 319 | 143 (44.8%), 176 (55.2%) | NS | Pediatric | 8.0 ± 4.9 y | 18.0 ± 4.9 (10-35,) | 10 ± 5.0 y |
| Lucas et al. 34 | NS | Prospective | Single-center | 134 | 105 (78.4%), 29 (21.6%) | NS | Pediatric | NS | 20.52 y (5.28, 14-39) | 13.12 ± 6.26 y (5-32) |
| Hickmann et al. 38 | Oct 2010- Dec 2012 | Prospective | Single-center | 83 | 36 (43.4%), 47 (56.6%) | NS | Adult | 51.9 ± 12.8 y (20.5-76.8) | NA | NA |
| Pranckeviciene et al. 37 | May 2010- Dec 2011 | Prospective | Single-center | 211 | 64 (30.3%), 147 (69.7%) | NS | Adult | 55.9 ± 15.4 y | NA | NA |
| Saad et al. 35 | Jan 2000- Dec 2016 | Retrospective | Multi-center | 87785 | 48908 (55.7%), 38877 (44.3%) | White (75616, 86.1%), black (6511, 7.42%), Asian or Pacific islander (5258, 5.99%), other (400, 4.56%) | Adult (76218, 86.8%), and pediatric (11657, 13.3%) | NS | NS | NS |
| Zhou et al. 36 | 1975-2015 | Retrospective | Multi-center | 115668 | 65017 (65.2%), 50651 (43.8%) | White (10134, 87.6%), black/ African American (7702, 6.66%), other (6621, 5.72%) | Adult and pediatric | NS | NS | NS |
F, female; M, male; NS, not specified; SD, standard deviation; Y, years.