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. 2023 May 30;100(22):e2224–e2236. doi: 10.1212/WNL.0000000000207240

Figure 6. Meta-analysis of Predictable Timing of Participants With Migraine for (A) the Presence or Absence of a Circadian Pattern, (B) the Circadian Pattern of Attacks Hour by Hour, or (C) the Circannual Pattern of Attacks Month by Month.

Figure 6

Rayleigh test data (in red) is shown for mean, length, and p value. The average time across all attacks (red arrows) was 14.13 hours and 7.4 months or 14:08 on July 12. Both the hour-by-hour and month-by-month data were significantly different between cluster headache and migraine (Watson 2 test p < 0.01). Of note, a single participant could respond once for A but multiple times for B or C. Additional analysis, including bar graphs, circadian 2-hour blocks, individual contributions from each study, and raw data, is available in eFigures 3 and 4 (links.lww.com/WNL/C706 and links.lww.com/WNL/C707) and eTables 7–9 (links.lww.com/WNL/C709).