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. 2023 May 30;100(22):e2224–e2236. doi: 10.1212/WNL.0000000000207240

Figure 7. Clock-Controlled Genes for Migraine (First Column) and the Specific Tissues in Which They Cycle (First Row).

Figure 7

Given the numerous genes involved in migraine, here we show a subset, namely all migraine genes that cycle in the thalamus, hypothalamus, brainstem, or cerebellum (green and blue). For the full uncondensed dataset, including genes that cycle in only cortical and subcortical areas, see eTable 14 (links.lww.com/WNL/C709). Tissues from red (prefrontal cortex) to blue (thalamus) were determined to be relevant in the pathophysiology of migraine (tissues colored shades of purple were not relevant). Cbl = cerebellum. *The other brain areas category consists of 3 tissues (habenula, olfactory bulb, and mammillary body) that were not mentioned as relevant in the pathophysiology of migraine.