Table 1.

Frequency of cancer in patients with non-functioning pituitary tumour, prolactinoma and acromegaly compared with the general population (GP) and with the internal control group (Graves’ disease–GD). Reproduced with permission from John Wiley and Sons Ltd from Popovic et al. (1998). © 1998.

Tumor	Number of patients	Patient-years	Observed	Malignancy		SIR-GP (95% CI)	SIR-GD (95% CI)
				Expected (GP)	Expected (GD)
Non-functioning
All	151	609	11	2.56	2.70	3.91(1.88–7.19)a	4.07 (2.03–7.29)a
Female	86	371	4	1.19	1.29	2.52 (0.52–7.36)	3.10 (0.84–7.94)
Male	65	238	7	1.26	2.31	5.56 (2.·23–11.45)a	3.03 (1.22–6.24)a
Prolactinoma
All	98	522	2	2.19	2.32	0.91 (0.11–3.29)	0.86 (0.10–3.10)
Female	67	366	2	1.17	1.28	1.71 (0.21–6.17)	1.56 (0.19–5.64)
Male	31	156	0	0.83	1.51	0 –	0 –
Acromegaly
All	220	1546	23	6.49	6.86	3.39 (2.12–5.12)a	3.21 (2.01–4.85)a
Female	137	936	14	2.99	3.26	4.35 (2.31–7.44)a	3.99 (2.12–6.82)a
Male	83	610	9	3.23	5.92	2.78 (1.27–5.28)a	1.52 (0.70–2.89)

^aP< 0.01.