Table 2.

Expression of the genes of AR-interacting proteins in different metastatic sites compared to samples from all other sites (bulk sequencing).

Bone metastasis	Higher expression in bone metastasis
	BAG1, JAZF1, JDP2, VDR, APOBEC3A, CCND3, CMTM2, E2F2, E2F4, FOXO4, NCOA4, PADI4, PTEN, PTK2B.
	Less expression in bone metastasis
	NR2F2, PROX1, SIX3, PRPF6, NCOA5, PELP1, RERE, SREBF2, SUPT6H, ZMIZ1, ZMIZ2, KDM1A, CRTC3, EHMT2, KAT7, MED24, NCOA6, NCOR2, PARP1, PIAS4, PPARD, PPP5C, PSMC4, RAD54L2, SAFB, SMARCA4, SRCIN1, TRIM28, ZNF318.
Liver metastasis	Higher expression in liver metastasis
	PROX1, SIX3, BAG1, APPBP2, NCOA1, NUMA1, PRKCD, UNC45A, HDAC3, CDK9, DAP3, RACK1, GSN, HSPA8, LATS2, PIAS3, PRMT1, PRMT2, RCHY1, RPL7, RPL7A, SMARCA2, AKR1C1, APOBEC3B, GADD45A, HNF4A, SATB1, SULT1E1, HSD17B7, SRD5A1, FEN1, AKR1C2, AURKA, BCL11B, BRCA1, CCNE1, CDC25A, CDC25B, CDC7, E2F1, NR1H4, NR6A1, HHEX, HSD17B13, HSD17B2, JUN, NR1H3, MCM2, MCM3, MCM4, MCM8, MUC1, NR0B2, NR1I2, POU4F2, PPARA, PPARGC1A, RORA, SOX4, SQSTM1, SRD5A2, TPX2.
	Less expression in liver metastasis
	NR2F2, PROX1, SIX3, BAG1, APPBP2, NCOA1, NUMA1, PRKCD, UNC45A, HDAC3, CDK9, DAP3, RACK1, GSN, HSPA8, LATS2, PIAS3, PRMT1, PRMT2, RCHY1, RPL7, RPL7A, SMARCA2.
Lymph node metastasis	Higher expression in lymph node metastasis
	NR2F2, PRPF6, NCOA5, PELP1, RERE, SREBF2, SUPT6H, ZMIZ1, ZMIZ2, APPBP2, NCOA1, NUMA1, PRKCD, UNC45A, SF1, AR, DDX54, FKBP4, FKBP5, FLII, HDAC1, NRIP2, PDPK1, RELA, SPDEF, SREBF1, TSC2.
	Less expression in lymph node metastasis
	PROX1, JAZF1, JDP2, VDR, AKR1C1, APOBEC3B, GADD45A, HNF4A, SATB1, SULT1E1.
Lung metastasis	Higher expression in lung metastasis
	HSD17B7, SRD5A1, SMARCE1, FHL2, PIAS2, SAP30, STAT3, TMF1.
	Less expression in lung metastasis
	SF1, ARID1A, CREBBP, MED12, SIN3B.
Prostate	Higher expression in primary PCa
	AKR1C2, FHL2, AKR1C3, CAV1, CCNA1, CRABP2, ESR1, ESR2, FLNA, FOXO1, HR, HSD17B8, NR4A3, NRBF2, PLAGL1, SMAD3, SUB1, TRIP10.
	Less expression in primary PCa
	PRPF6, HDAC3, FEN1, SMARCE1, AKT1, ANP32A, NELFB, DHX9, EDF1, FUS, MTA2, PA2G4, PSMC5, PSME3, SET, SMAD4, TRIM24.