Table 3.

Expression of the genes of AR-interacting proteins in cancer vs stroma.

A) Micro-dissected tissue: cancer vs cancer adjacent stroma (CAS)

More highly expressed in PCa

ANP32A, APPBP2, AR, ARID1A, CALR, CDK5, CDK7, CMTM2, COPS5, CTBP1, EDF1, EHMT2, FKBP4, FKBP5, FUS, GADD45G, RACK1, HNF4G, HSD17B4, HSPA8, MCM2, KMT2D, MNAT1, MPG, MTOR, NCOA4, NCOA5, NCOA6, NELFB, NFYA, NONO, NUMA1, PARK7, PDPK1, PHB2, PPID, PRKCD, RANBP9, RBM14, RBM39, RERE, RPL7, RPL7A, SCAND1, SFPQ, SMAD4, SMARCA4, SOX4, SPDEF, TBL1XR1, TGIF1, TRIM24, TRIM28, TXNRD2, UNC45A, XBP1.

More highly expressed in CAS

AKR1C3, APOBEC2, APOBEC3C, BCL11B, CAV1, CDKN1C, ESR1, FHL2, FLNA, FOXO1, GADD45A, GADD45B, GATA3, GSN, HMGB2, JAZF1, JDP2, LMO4, MGMT, NR0B1, NR1D2, NR2F1, NR2F2, NR3C1, NR3C2, NR4A3, PTEN, RARA, RARB, RARG, RBFOX2, RHEB, RORA, SKI, SMAD3, SRD5A2, SVIL, TAGLN, TCF21, TGFB1I1, YWHAH, ZFPM2, ZYX.

B) Comparison between cell line models

More highly expressed in cancer cells

AIP, ANKRD11, APPL1, AR, AURKA, BAG1, BLOC1S1, BRD8, CALR, CDC7, CDK5, CDKN1C, CDKN3, CDT1, COPS5, CRIPAK, CRTC1, CRTC2, CTBP2, DAP3, DDX5, DDX54, E2F2, E2F3, EDF1, ESRRA, FAF1, FKBP4, FUS, GADD45G, GADD45GIP1, RACK1, H2AZ1, HDAC1, HDAC2, HMGB2, HSD17B1, HSD17B4, HSD17B8, MCM2, MCM3, MED30, MMS19, MTA1, NCOA4, NCOA6, NCOR2, PA2G4, PAK6, PARK7, PARP1, PELP1, PIAS3, PIN1, PPID, PRAME, PRMT1, PRMT6, PRPF6, PSMC3IP, PSMC5, PTK2B, PTMA, PTMS, PUS3, RAN, RBM14, RBM39, RNF4, RPL7, RPL7A, RXRA, SET, SF1, SIN3B, SMARCA4, SMARCD3, SMARCE1, SNW1, SPDEF, SREBF1, SREBF2, TBL1X, TDG, TGS1, TRIM24, TRIM28, TRIP13, TXN, UBE2I, UGT2B11, UIMC1, VAV3, XBP1, XRCC6, ZMIZ2, ZNF461, ZNHIT3

More highly expressed in fibroblast cell lines

APOBEC1, APOBEC2, APOBEC3A, APOBEC3C, CAV1, CCNA1, CDK6, CMTM2, EFCAB6, FHL2, FOXG1, GATA3, GSN, HHEX, HNF4A, HSD17B13, HSD17B2, HSD3B1, JAZF1, KMT2D, MUC1, NEDD4, NQO1, NR2F1, NR5A1, PADI4, PLAGL1, PPARG, PROX1, RARB, RXRG, SENP1, SMAD3, STAT3, STS, TAGLN, TCF21, TGFB1I1, ZFPM2.

More highly expressed in cancer cells

TLE5, AIP, AKT1, ANKRD11, APOBEC3B, APPL1, AR, AURKA, BAG1, BLOC1S1, BRCA1, BRD8, CALR, CARM1, CASP8AP2, CCNA2, CCND1, CCNE1, CDC25A, CDC7, CDK5, CDK7, CDK9, CDKN1C, CDKN3, CDT1, CITED2, CRTC1, DAP3, DAXX, DDX54, DHX9, E2F1, E2F2, E2F3, EDF1, EHMT2, ELL, ESRRA, FAF1, FEN1, FKBP4, FKBP5, FLII, FOXH1, FOXO4, FUS, GADD45B, GADD45G, GADD45GIP1, GMEB1, H2AZ1, HDAC1, HDAC2, HDAC3, HDAC4, HMGB2, HNF4G, HSD17B1, HSD17B11, HSD17B4, HSD17B8, MCM10, MCM2, MCM3, MCM4, MCM5, MCRS1, MED14, MED24, MGMT, MMS19, MNAT1, MTA1, MTA2, NCOA4, NCOA6, NCOR1, NCOR2, NFYC, NRIP1, PA2G4, PARK7, PARP1, PDPK1, PELP1, PIAS2, PIAS3, PIAS4, PIN1, PPARA, PPID, PPM1D, PPRC1, PRAME, PRKCD, PRMT1, PRMT5, PRPF6, PSMC3, PSMC3IP, PSMC4, PSMC5, PSME3, PTK2B, PTMS, PUS1, PUS3, RAD54L2, RARA, RB1, RBM14, RBM39, RCC1, RNF14, RNF4, RORB, RXRA, SAFB, SAFB2, SAP30, SCAND1, SET, SF1, SFPQ, SGTA, SIN3B, SMAD4, SMARCA4, SMARCD3, SMARCE1, SNW1, SPDEF, SREBF1, SREBF2, SS18, TBL1X, TBL1XR1, TDG, TGS1, THRA, TPX2, TRIM24, TRIM25, TRIM28, TRIP11, TRIP12, TRIP13, TRIP4, TRRAP, TSC2, TXN, UBE2I, UBE3A, UIMC1, UNC45A, UXT, VDR, XBP1, XRCC6, ZMIZ1, ZMIZ2, ZNF318, ZNHIT3.

More highly expressed in benign cell lines

AKR1C1, APOBEC2, APOBEC3C, CAV1, CCNA1, CYP19A1, FHL2, GATA3, GSN, HIF1A, HNF4A, HSD17B2, NQO1, NR1D1, PLAGL1, PROX1, RARB, RXRG, TAGLN, TCF21, ZFPM2.