2. Reasons for review exclusion.

Reason for exclusion	Papers excluded
Ineligible study design	Aiyer 2018*; Bussa 2015*; De Souza 2015*; Dirckx 2012*; Dworkin 2013*; Friend 2022*; Galafassi 2021*; Jadad 1995*; Nagpal 2021*; Roche Bueno 2020*; Soin 2021*; Wang 2021**; Wertli 2014**; Żyluk 2018*
Insufficient CRPS exclusivity	Aamir 2020; Aiyer 2016; Andreae 2015; Balanaser 2022; Bies 2022; Birse 2012; Boychuk 2015; Boyd 2019; Brookes 2017; Buksnys 2020; Casale 2021; Chaparro 2012; Cooper 2017; Corrigan 2012; Datta Gupta 2022; David 2018; Deer 2020; Derry 2012a; Derry 2012b; Derry 2013; Derry 2014; Derry 2015a; Derry 2015b; Derry 2016; Derry 2017b; Derry 2019; Di Stefano 2021; Duarte 2020; Duehmke 2017; Dykukha 2021; Eccleston 2015; Finnerup 2015; Gallagher 2015; Gaskell 2014; Gaskell 2016; Gibson 2017; Hary 2022; Hearn 2012; Hearn 2014a; Hearn 2014b; Hoydonckx 2019; Iskedjian 2007; Jia 2022; Jiang 2022; Jin 2015; Ju 2017; Julian 2020; Jupudi 2021; Kapustin 2020; Knezevic 2020; Li 2015b; Liao 2017; Lunn 2014; Mailis‐Gagnon 2004; Markman 2017; Martins de Andrade 2016; McNicol 2013; McNicol 2017; McParland 2021; Meng 2017; Mohiuddin 2021; Moisset 2020; Moore 2012; Moore 2015a; Moore 2015b; Moore 2015c; Mu 2017; Mücke 2018; Ney 2013; O'Connell 2010; Petzke 2016; Shi 2016; Shin 2021; Silvinato 2020; Singh 2017; Sommer 2020; Stannard 2016; Thieme 2016; Tremont‐Lukats 2005; Vargas‐Espinosa 2012; Wang 2017b; Wei 2019; Wiffen 2013a; Wiffen 2013b; Wiffen 2014a; Wiffen 2014b; Wiffen 2015; Wiffen 2016; Wiffen 2017; Zhou 2017; Wrzosek 2015
No novel coverage in addition to existing Cochrane reviews or other included reviews	Azari 2012; Brunner 2009; Chitneni 2021; Collins 2010; Connolly 2015; Daly 2009; Fabregat 2013; Gatzinsky 2021; Grabow 2003; Lu 2009; Matuschek 2017; Méndez‐Rebolledo 2017; Nardone 2018; Oh 2015; Pearl 2020; Perez 2001; Rothgangel 2011; Selph 2011; Siongco 2020; Simpson 2009; Turner 2004; Van den Berg 2022; Visnjevac 2017
Previous version of already included review	Cepeda 2005; Moore 2011; Stanton 2013; Smart 2016; Straube 2010
Did not report outcomes relevant to this overview	Lin 2012; Packham 2018
Included randomised and non‐randomised studies but did not report separately	Zhao 2018

*Not a systematic review that satisfied a judgement of 'Yes' on third AMSTAR criterion (Shea 2007)

**Excluded due to unclear network meta‐analysis methodology and uninterpretable effect estimates