Table 3.
Change in Medication Burden
| Outcome: Medication Burden | PEcK | Phaco/ECP | Phaco/KDB | |||
|---|---|---|---|---|---|---|
| N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | |
| Baseline | 128 | 3.0 (1.4) | 78 | 2.2 (1.5) | 65 | 0.4 (1.0) |
| 6 weeks | 114 | 1.7 (1.4) | 72 | 1.3 (1.4) | 63 | 0.4 (1.0) |
| 3 months | 79 | 1.6 (1.3) | 58 | 1.3 (1.4) | 41 | 0.3 (0.7) |
| 6 months | 102 | 1.7 (1.4) | 63 | 1.2 (1.3) | 53 | 0.3 (0.9) |
| 12 months | 78 | 1.9 (1.4) | 43 | 1.4 (1.4) | 31 | 0.3 (0.7) |
| 18 months | 56 | 2.0 (1.4) | 30 | 1.7 (1.3) | 18 | 0.5 (1.0) |
| 24 months | 42 | 2.1 (1.5) | 31 | 1.5 (1.6) | 11 | 0.3 (0.5) |
| 36 months | 19 | 2.1 (1.6) | 27 | 1.5 (1.6) | 2 | 0.0 (0.0) |
| 48 months | 3 | 3.0 (1.0) | 14 | 1.6 (1.5) | 0 | – |
| 60 months | 0 | – | 9 | 2 (1.5) | 0 | – |
| P-values: Evaluating the pattern of change | ||||||
| Over time, unadjusted | 0.001* | |||||
| Over time, adjusteda | <0.001* | |||||
| Comparing procedure to PEcK over time, unadjusted | – | 0.15 | 0.04* | |||
| Comparing procedure to PEcK over time, adjusteda | – | 0.09 | 0.13 | |||
| Comparing all procedures over time, unadjusted | 0.11 | |||||
| Comparing all procedures over time, adjusteda | 0.17 | |||||
Notes: Mean medication burden and mean reduction in medications at postoperative timepoints. Wald Tests with and without adjustment for baseline IOP were used to evaluate difference between the pattern of change across timepoints and the pattern of change between all timepoints and the two procedures. aAdjusted GEE for medication burden included co-variates for baseline IOP, prior laser trabeculoplasty, glaucoma type, and sex. *Asterisk identifies significance defined as p < 0.05. All bolded text is used to distinguish column and section headers of the table.
Abbreviations: Phaco/ECP, phacoemulsification and endocyclophotocoagulation (ECP); Phaco/KDB, phacoemulsification and Kahook Dual Blade; PEcK, phacoemulsification, ECP, and KDB.