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. 2023 Jun 8;18:3087–3107. doi: 10.2147/IJN.S406314

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© 2023 Xia et al.

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Analysis of the S₆₀-αTSR nanoparticles after purification by cesium chloride (CsCl) density gradient centrifugation. (A) Following centrifugation, the CsCl density gradient containing the S₆₀-αTSR nanoparticles was fractionated into 22 portions. The relative concentrations of the S₆₀-αTSR protein in the fractions were measured by EIA assays using antibody against norovirus VLP. Y-axis indicates the fraction numbers, while X-axis shows signal intensities in optical density (OD₄₅₀) with a red dashed line showing the cut-off signal at OD₄₅₀=0.1. (B and C) A TEM micrograph of the S-αTSR protein of fraction 17 showing uniform S₆₀-αTSR nanoparticles (B) with an enlargement of the framed area in (C) showing recognizable protrusions of αTSR antigens on the surface.