Table 2.
Posterior inclusion probabilities (PIPs) into infant neurodevelopment measured by the Bayley Scales of Infant Development second edition (BSID-II) by Bayesian kernel machine regression (BKMR) model in the Hokkaido Study Small Cohort (n = 259).
| Dioxin and PCB congeners | Individual PIP | Group PIP | Conditional PIP |
|---|---|---|---|
| (a) Mental Developmental Index (MDI) | |||
| PCDD | |||
| 2,3,7,8-TCDD | 0.03 | 0.23 | 0.16 |
| 1,2,3,7,8-PeCDD | 0.06 | 0.55 | |
| 1,2,3,4,7,8-HxCDD | <0.01 | 0.04 | |
| 1,2,3,6,7,8-HxCDD | <0.01 | 0.01 | |
| 1,2,3,7,8,9-HxCDD | <0.01 | 0.02 | |
| 1,2,3,4,6,7,8-HpCDD | 0.08 | 0.16 | |
| OCDD | <0.01 | 0.06 | |
| PCDF | |||
| 2,3,7,8-TCDF | 0.02 | 0.16 | 0.05 |
| 1,2,3,7,8-PeCDF | <0.01 | 0.07 | |
| 2,3,4,7,8-PeCDF | 0.01 | 0.05 | |
| 0.0141,2,3,4,7,8-HxCDF | 0.02 | 0.01 | |
| 1,2,3,6,7,8-HxCDF | 0.03 | 0.60 | |
| 2,3,4,6,7,8-HxCDF | 0.05 | 0.21 | |
| 1,2,3,4,6,7,8-HpCDF | <0.01 | <0.01 | |
| OCDF | <0.01 | <0.01 | |
| Non-ortho DL-PCB | |||
| 33′44′-TCB(#77) | 0.11 | 0.19 | 0.91 |
| 33′44′5-PenCB(#126) | <0.01 | 0.05 | |
| 33′44′55′-HxCB(#169) | <0.01 | 0.04 | |
| Mono-ortho DL-PCB | |||
| 2′344′5-PeCB(#123) | 0.02 | 0.03 | 0.22 |
| 23′44′5-PeCB(#118) | <0.01 | 0.02 | |
| 2344′5-PeCB(#114) | <0.01 | 0.09 | |
| 233′44′-PeCB(#105) | <0.01 | 0.04 | |
| 23′44′55′-HxCB(#167) | <0.01 | 0.08 | |
| 233′44′5-HxCB(#156) | <0.01 | 0.14 | |
| 233′44′5′-HxCB(#157) | <0.01 | 0.41 | |
| Di-ortho DL-PCB | |||
| 22′33′44′5-HpCB(#170) | <0.01 | <0.01 | NA |
| 22′344′55′-HpCB(#180) | <0.01 | NA | |
| (b) Psychomotor Developmental Index (PDI) | |||
| PCDD | |||
| 2,3,7,8-TCDD | <0.01 | 0.20 | 0.06 |
| 1,2,3,7,8-PeCDD | <0.01 | 0.08 | |
| 1,2,3,4,7,8-HxCDD | 0.02 | 0.18 | |
| 1,2,3,6,7,8-HxCDD | <0.01 | 0.05 | |
| 1,2,3,7,8,9-HxCDD | 0.03 | 0.08 | |
| 1,2,3,4,6,7,8-HpCDD | 0.15 | 0.47 | |
| OCDD | 0.10 | 0.09 | |
| PCDF | |||
| 2,3,7,8-TCDF | <0.01 | 0.22 | 0.11 |
| 1,2,3,7,8-PeCDF | 0.08 | 0.53 | |
| 2,3,4,7,8-PeCDF | 0.01 | 0.07 | |
| 1,2,3,4,7,8-HxCDF | <0.01 | 0.06 | |
| 1,2,3,6,7,8-HxCDF | 0.02 | 0.14 | |
| 2,3,4,6,7,8-HxCDF | 0.05 | 0.09 | |
| 1,2,3,4,6,7,8-HpCDF | <0.01 | <0.01 | |
| OCDF | <0.01 | <0.01 | |
| Non-ortho DL-PCB | |||
| 33′44′-TCB(#77) | 0.01 | 0.18 | 0.25 |
| 33′44′5-PenCB(#126) | 0.02 | 0.57 | |
| 33′44′55′-HxCB(#169) | 0.01 | 0.18 | |
| Mono-ortho DL-PCB | |||
| 2′344′5-PeCB(#123) | 0.03 | 0.50 | 0.07 |
| 23′44′5-PeCB(#118) | 0.06 | 0.10 | |
| 2344′5-PeCB(#114) | 0.04 | 0.08 | |
| 233′44′-PeCB(#105) | 0.06 | 0.08 | |
| 23′44′55′-HxCB(#167) | 0.22 | 0.37 | |
| 233′44′5-HxCB(#156) | 0.01 | 0.12 | |
| 233′44′5′-HxCB(#157) | 0.07 | 0.18 | |
| Di-ortho DL-PCB | |||
| 22′33′44′5-HpCB(#170) | 0.02 | 0.03 | 0.70 |
| 22′344′55′-HpCB(#180) | <0.01 | 0.30 | |
Models were adjusted for maternal age, education, household income, work status during pregnancy, smoking status during pregnancy, and fish intake during pregnancy (inshore and deep-sea fish).