Table 3.
Quantile-based g-computation estimates per quantile increase in the mixture of log-transformed dioxins and DL-PCBs with congener-specific weights in relation to infant neurodevelopment measured by the Bayley Scales of Infant Development second edition (BSID-II) (n = 259).
| (a) Mental Developmental Index (MDI) | |||
|---|---|---|---|
| Estimate (95% CI)a | P | Weights | |
| −2.61 (−5.70, 0.49) | 0.10 | ||
| Positive direction | Sum of positive coefficients = 7.45 | ||
| 1,2,3,7,8,9-HxCDD | 0.28 | ||
| 23′44′5-PeCB(#118) | 0.16 | ||
| 33′44′-TCB(#77) | 0.15 | ||
| 233′44′5-HxCB(#156) | 0.15 | ||
| 33′44′55′-HxCB(#169) | 0.11 | ||
| 2,3,4,7,8-PeCDF | 0.08 | ||
| 2′344′5-PeCB(#123) | 0.05 | ||
| 1,2,3,7,8-PeCDD | 0.01 | ||
| 1,2,3,6,7,8-HxCDF | 0.01 | ||
| Negative direction | Sum of negative coefficients = −10 | ||
| 2,3,7,8-TCDD | 0.30 | ||
| 1,2,3,4,7,8-HxCDD | 0.19 | ||
| 233′44′-PeCB(#105) | 0.12 | ||
| 33′44′5-PenCB(#126) | 0.06 | ||
| 1,2,3,4,7,8-HxCDF | 0.06 | ||
| 23′44′55′-HxCB(#167) | 0.05 | ||
| 233′44′5′-HxCB(#157) | 0.05 | ||
| OCDD | 0.04 | ||
| 22′344′55′-HpCB(#180) | 0.04 | ||
| 2344′5-PeCB(#114) | 0.03 | ||
| 2,3,7,8-TCDF | 0.03 | ||
| 1,2,3,6,7,8-HxCDD | 0.02 | ||
| 1,2,3,4,6,7,8-HpCDF | 0.01 | ||
| 1,2,3,4,6,7,8-HpCDD | 0.01 | ||
| 22′33′44′5-HpCB(#170) | <0.01 | ||
| 1,2,3,7,8-PeCDF | <0.01 | ||
| 2,3,4,6,7,8-HxCDF | <0.01 | ||
| OCDF | <0.01 | ||
| (b) Psychomotor Developmental Index (PDI) | |||
| Estimate (95% CI)a | P | Weights | |
| −4.71 (−10.35, 0.94) | 0.10 | ||
| Positive direction | Sum of positive coefficients = 7.94 | ||
| 2,3,4,7,8-PeCDF | 0.19 | ||
| 233′44′-PeCB(#105) | 0.18 | ||
| 1,2,3,7,8-PeCDD | 0.16 | ||
| 1,2,3,6,7,8-HxCDF | 0.16 | ||
| 2344′5-PeCB(#114) | 0.10 | ||
| 22′344′55′-HpCB(#180) | 0.09 | ||
| OCDD | 0.07 | ||
| 1,2,3,4,6,7,8-HpCDF | 0.04 | ||
| 33′44′-TCB(#77) | 0.02 | ||
| Negative direction | Sum of negative coefficients = −12.6 | ||
| 2,3,7,8-TCDD | 0.14 | ||
| 33′44′5-PenCB(#126) | 0.13 | ||
| 1,2,3,4,7,8-HxCDF | 0.12 | ||
| 233′44′5′-HxCB(#157) | 0.08 | ||
| 1,2,3,4,6,7,8-HpCDD | 0.08 | ||
| 22′33′44′5-HpCB(#170) | 0.07 | ||
| 233′44′5-HxCB(#156) | 0.07 | ||
| 1,2,3,4,7,8-HxCDD | 0.06 | ||
| 23′44′5-PeCB(#118) | 0.05 | ||
| 23′44′55′-HxCB(#167) | 0.05 | ||
| 33′44′55′-HxCB(#169) | 0.05 | ||
| 2,3,7,8-TCDF | 0.04 | ||
| 1,2,3,7,8,9-HxCDD | 0.02 | ||
| 2′344′5-PeCB(#123) | 0.02 | ||
| 1,2,3,6,7,8-HxCDD | 0.01 | ||
| 1,2,3,7,8-PeCDF | <0.01 | ||
| 2,3,4,6,7,8-HxCDF | <0.01 | ||
| OCDF | <0.01 | ||
Models were adjusted for maternal age, education, household income, work status during pregnancy, smoking status during pregnancy, and fish intake during pregnancy (inshore and deep-sea fish).
a
β can be interpreted as the change in the BSID-II score for one quartile increase in all dioxins and DL-PCBs based on 200 bootstrap iterations.