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. 2023 Jun 12;11(6):e5051. doi: 10.1097/GOX.0000000000005051

Table 1.

Exosome Products and Manufacturers

Name (City, State, Country) Source Cells/Derivative Constituents (Exosome Concentration in Billions) per Unit Storage °C Delivery Thawing/Reconstitution Process Shelf Life before/after Reconstitution or Thawing Advertised Utilization Approximate Surface Area for Treatment Cost per Treatment of Face (USD)
Benev (Mission Viejo, CA, USA) Adult adipose stem cell 20 mL lyophilized exosome (2.5 or 5 billion) +5 mL diluent (hyaluronic acid, growth factors, coenzymes, vitamins) Room temperature Shipped frozen with ice pack Reconstitute with the provided diluent or saline 2 wk/20 min Topical for facial rejuvenation and hair restoration 1–2 mL per face $68–116
Direct Biologics (Austin, TX, USA) Adult bone marrow stem cell 1 mL exosome + 9 mL saline −40 to −80, not in liquid nitrogen N/A No additional process required 5 y/- Topical for facial rejuvenation 1-2 mL per face N/A
Exocel Bio (San Diego, CA, USA) Placental chorion stem cell Exosome (5, 12, 25, 100, or 400 billion) mixed with 2–5 mL saline -80 Shipped on dry ice Use as it is after thawing or can reconstitute 1:1 with saline 6 mo–1 y/1 h Topical for facial rejuvenation and hair restoration 1–2 mL per face $150–4950
Kimera (Miramar, FL, USA) Placental chorionic and amniotic stem cell Exosome (1 or 5 billion) mixed with 1–5 mL saline −20, not in liquid nitrogen Shipped on dry ice No additional process required 1 y/48 h Topical for facial rejuvenation, hair restoration (or scalp injection), and scar revision 1 mL per face, and 5 mL for face, neck, and décolleté $200–550
Regan Suppliers (Scottsdale, AZ, USA) Wharton’s Jelly stem cell Exosome mixed with saline (1.5 billion) −80 Shipped on dry ice After thawing, reconstitute 1:3 exosome to saline 1 y/1 h Topical and injection for facial rejuvenation and hair restoration 1 mL per area of injection, 2 mL for hair, and 5 mL IV $775–1075
Elevai (Newport Beach, CA, USA) Wharton’s Jelly stem cell Exosome serum 5 mL Room temperature N/A No additional process required 1 y/- Topical for facial rejuvenation and depigmentation 1 mL per face $75–149
Disclose–no financial interest

HA, hyaluronic acid.