Table 1.
Exosome Products and Manufacturers
Name (City, State, Country) | Source Cells/Derivative | Constituents (Exosome Concentration in Billions) per Unit | Storage °C | Delivery | Thawing/Reconstitution Process | Shelf Life before/after Reconstitution or Thawing | Advertised Utilization | Approximate Surface Area for Treatment | Cost per Treatment of Face (USD) |
---|---|---|---|---|---|---|---|---|---|
Benev (Mission Viejo, CA, USA) | Adult adipose stem cell | 20 mL lyophilized exosome (2.5 or 5 billion) +5 mL diluent (hyaluronic acid, growth factors, coenzymes, vitamins) | Room temperature | Shipped frozen with ice pack | Reconstitute with the provided diluent or saline | 2 wk/20 min | Topical for facial rejuvenation and hair restoration | 1–2 mL per face | $68–116 |
Direct Biologics (Austin, TX, USA) | Adult bone marrow stem cell | 1 mL exosome + 9 mL saline | −40 to −80, not in liquid nitrogen | N/A | No additional process required | 5 y/- | Topical for facial rejuvenation | 1-2 mL per face | N/A |
Exocel Bio (San Diego, CA, USA) | Placental chorion stem cell | Exosome (5, 12, 25, 100, or 400 billion) mixed with 2–5 mL saline | -80 | Shipped on dry ice | Use as it is after thawing or can reconstitute 1:1 with saline | 6 mo–1 y/1 h | Topical for facial rejuvenation and hair restoration | 1–2 mL per face | $150–4950 |
Kimera (Miramar, FL, USA) | Placental chorionic and amniotic stem cell | Exosome (1 or 5 billion) mixed with 1–5 mL saline | −20, not in liquid nitrogen | Shipped on dry ice | No additional process required | 1 y/48 h | Topical for facial rejuvenation, hair restoration (or scalp injection), and scar revision | 1 mL per face, and 5 mL for face, neck, and décolleté | $200–550 |
Regan Suppliers (Scottsdale, AZ, USA) | Wharton’s Jelly stem cell | Exosome mixed with saline (1.5 billion) | −80 | Shipped on dry ice | After thawing, reconstitute 1:3 exosome to saline | 1 y/1 h | Topical and injection for facial rejuvenation and hair restoration | 1 mL per area of injection, 2 mL for hair, and 5 mL IV | $775–1075 |
Elevai (Newport Beach, CA, USA) | Wharton’s Jelly stem cell | Exosome serum 5 mL | Room temperature | N/A | No additional process required | 1 y/- | Topical for facial rejuvenation and depigmentation | 1 mL per face | $75–149 |
Disclose–no financial interest |
HA, hyaluronic acid.