Table 4.

General Linear model/Univariate analyses of covariance of neuropeptides across fixed factor variables controlling for age and time of blood draw as covariates.

Cases	Neuropeptides	Categorical Variables		Statistics
		Subgroup 1	Subgroup 2	ANCOVA adjusted for Age and Time of Blood Draw
		Mean ± SE	Mean ± SE	F	p-value
Full Cohort	Ln Plasma OT
	Group Allocation	PWS	Control
		5.143 (0.093)	5.201 (0.093)	0.184	0.669
	Sex	Male	Female
		5.159 (0.094)	5.185 (0.094)	0.037	0.848
	Ln Plasma AVP
	Group Allocation	PWS	Control
		3.142 (0.064)	3.096 (0.060)	6.564	0.013
	Sex	Male	Female
		3.032 (0.063)	3.206 (0.062)	1.058	0.308
	Ln Saliva OT
	Group Allocation	PWS	Control
		3.142 (0.064)	3.096 (0.060)	0.266	0.608
	Sex	Male	Female
		3.032 (0.063)	3.206 (0.062)	3.729	0.059
PWS only	Ln Plasma
	Genetic Subtype	mUPD	Deletion
		5.259 (0.133)	5.190 (0.109)	0.163	0.691
	Sex	Male	Female
		5.182 (0.100)	5.267 (0.140)	0.243	0.627
	Ln Plasma AVP
	Genetic Subtype	mUPD	Deletion
		3.880 (0.221)	3.872 (0.182)	0.001	0.977
	Sex	Male	Female
		3.826 (0.167)	3.926 (0.234)	0.121	0.732
	Ln Saliva OT
	Genetic Subtype	mUPD	Deletion
		3.319 (0.083)	3.107 (0.059)	4.398	0.050
	Sex	Male	Female
		3.087 (0.059)	3.340 (0.081)	6.543	0.020
PWS only	Ln Plasma OT
	Psychosis	Yes	No
		4.972 (0.219)	5.218 (0.100)	1.036	0.319
	Sex	Male	Female
		5.016 (0.134)	5.175 (0.165)	0.765	0.390
	Ln Plasma AVP
	Psychosis	Yes	No
		3.912 (0.312)	3.788 (0.143)	0.129	0.722
	Sex	Male	Female
		3.816 (0.192)	3.884 (0.235)	0.070	0.794
	Ln Saliva OT
	Psychosis	Yes	No
		3.319 (0.083)	3.107 (0.059)	2.642	0.120
	Sex	Male	Female
		3.087 (0.059)	3.340 (0.081)	5.492	0.030

Values highlighted in blue, and green are significant or near significant at p < 0.05 and p < 0.1, respectively.