Table 2. Sex and BMI Significantly Modify Metabolic Associations Influenced by PCOSPRS.
| Males | Females | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Phenotype | OR | LCI | UCI | P | OR | LCI | UCI | p | Interaction P Value |
| Hypertensive heart disease | 1.12 | 1.11 | 1.13 | 1.49 x10-104 | 1.10 | 1.09 | 1.11 | 3.09x10-102 | 7.13x10-6 |
| Diabetes mellitus | 1.11 | 1.10 | 1.11 | 6.63x10-286 | 1.10 | 1.09 | 1.10 | < 1x10-350 | 0.01 |
| Type 2 diabetes | 1.12 | 1.11 | 1.12 | < 1x10-350 | 1.11 | 1.10 | 1.11 | < 1x10-350 | 0.02 |
| Coronary atherosclerosis | 1.05 | 1.04 | 1.05 | 5.27 x10-53 | 1.04 | 1.03 | 1.05 | 7.73 x10-41 | 0.11 |
| Ischemic Heart Disease | 1.04 | 1.04 | 1.05 | 3.71 x10-48 | 1.04 | 1.03 | 1.04 | 1.07 x10-42 | 0.21 |
| Essential hypertension | 1.08 | 1.07 | 1.09 | 3.91 x10-188 | 1.08 | 1.07 | 1.08 | < 1x10-350 | 0.33 |
| Hypertension | 1.08 | 1.07 | 1.08 | 1.30 x10-183 | 1.08 | 1.07 | 1.08 | < 1x10-350 | 0.40 |
| Loss of teeth or edentulism* | – | – | – | – | 1.00 | 0.98 | 1.03 | 0.87 | 0.59 |
We used a logistic regression model to test the interaction of effect between sex and body mass index (BMI). The effect estimates for BMI from the stratified models are shown for males and females. The interaction model was adjusted for the interaction term, sex, BMI, PCOSPRS, age, and genetic ancestry. *Males did not meet the minimum case requirement (n ≥ 100).