Figure 8.

Spare respiratory capacity is increased in male offspring of dams fed a Western-style diet. Isolated islets were subjected to Agilent Seahorse Cell Mito Stress Test. A: oxygen consumption rate (OCR) profiles of islets assessed ex vivo. Basal respiration (B), maximal respiration (C), and ATP-linked respiration (D) were not changed in male or female WSD/WSD offspring. E: spare respiratory capacity was increased in islets of male WSD/WSD offspring. *P < 0.05, n = 9–13 per maternal diet group. Each color corresponds to a different offspring and open symbols denote female offspring in B and C. CD, control diet; WSD, Western-style diet.