Table 3. Selected cell signaling pathways regulated in patient-derived ECs.

GO	Term	Genes*
GO:0038127	ERBB signaling pathway	PRKCE,TNRC6C,PDE1A,AREG, RPS27A,TGFA,KITLG,ERBB2, PTK2B,DGKD,PRKAR2B,NRG1, RPS6KA5,PRKACB
GO:0043122	regulation of I-kappaB kinase/ NF-kappaB signaling	GREM1,LURAP1,BIRC3,TNFAIP3, S100A4,MALT1,LITAF,PRKCE, LPAR1,C18orf32,ZFAND6,RPS27A, PLK2,TLR4,F2RL1,CASP1,S100A13
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	RGS4,RGS9,DYNLT1,RGS11,CXCL8,RGS10,RGS20,RGS5,RAMP2,RGS7, PLCB1,ADRBK2
GO:0043410	positive regulation of MAPK cascade	PAK1,MAP4K2,SEMA4C,TGFA, GADD45G,KSR2,ERBB2,NENF, PLCB1,TPD52L1,GLIPR2,ICAM1, CD74,PRKCE,LPAR1,PDCD10,INSR, IGF1R,GADD45A,RPS27A,PTK2B, KITLG,HGF,F2RL1,TLR4,PIK3CG, ZEB2,EPGN
GO:0046328	regulation of JNK cascade	PAK1,MAP4K2,GADD45A,IGF1R, GADD45G,TNXB,PTK2B,CBS,SFRP1,PLCB1,F2RL1,TLR4,TPD52L1,ZEB2
GO:0007219	Notch signaling pathway	HEY2,NOTCH1,TNRC6C,RBX1, TMEM100,LFNG,RPS27A,E2F1, DTX3,NOTCH2,MESP1,DNER, FOXC1,SNAI2,HDAC9

^*ErbB pathway receptors and ligands are marked in bold.