Figure 1. Schematics of the PRLR:PRL:JAK2 complex in the membrane.

The PRLR is shown in light blue, the PRL as a dark blue triangle, the PRLR-ICD as a disordered chain, and JAK2 in purple. The PI(4,5)P₂ lipid (PIP2) is shown in orange. The intracellular juxtamembrane (ICJM) region and BOX1 of PRLR-ICD are highlighted in green nuances, while the three LIDs as defined in Haxholm et al., 2015 are highlighted in red. For simplicity, only one of the two ICDs is shown associated with JAK2 via the BOX1 (green) and BOX2 (orange) motifs. PRLR, prolactin receptor; ICD, intracellular domain; LID, lipid interaction domains.