Figure 6. Model of how co-structure formation between JAK2, prolactin receptor (PRLR), and PI4(4,5)P₂ may contribute to signaling fidelity.

The suggested states in signaling would be (A) the inactive state of the co-structure exemplified by the Flat orientation. (B) The hormone bound state expemplified by the co-structure in the Y orientation. (C) Phosphorylation of PIP(4,5)P₂ to PI(3,4,5)P₃ for which the PRLR has no affinity may lead to downregulation and/or termination of signaling. The color scheme of the proteins is identical to Figure 4.