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. 2023 May 25;55(6):927–938. doi: 10.1038/s41588-023-01398-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — Regional plot of educational attainment GWAS association test results were generated around top independent SNP rs10798888. Additional associations from GWAS catalog were annotated with the associated phenotypes in the regional plot. EDU and VNR score for ADGRB2 PTV carriers in UKB were plotted (both phenotypes were residualized by sex, age, age², sex by age, sex by age², top 20 PCs and recruitment centers and were inverse rank-based normal transformed). Samples with inpatient ICD-10 (International Classification of Diseases version-10) records of psychiatric, neurodegenerative, and neurodevelopmental disorders were annotated. The blue line (for EDU) and red line (for VNR) represent fitted loess regression on standardized, residualized phenotypes. The gray bands represent 95% confidence intervals for the fitted loess regression.