Extended Data Fig. 4. Kdm5b loss-of-function impacts craniofacial and skeletal features in mice in a dose-dependent manner.
An intermediate effect on cranial length (additive genotype effect two-sided P = 0.0268) and height (additive genotype effect two-sided P = 0.0056) is detected in Kdm5b+/− mice, but not in cranial width (additive genotype effect two-sided P = 0.3090). For the boxplot, the center line represents the median, the box limits represent the IQR, and the whiskers indicate the minimum and maximum values. A fully penetrant transitional vertebrae phenotype seen in Kdm5b−/− mice (N = 21) is observed at a lower frequency in Kdm5b+/− mice (N = 40, Fisher’s exact test vs Kdm5b+/+ two-sided P = 0.0189).