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. 2023 Jun 12;55(6):1066–1075. doi: 10.1038/s41588-023-01421-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a. UMAP shows the 18 different cell types annotated previously in the PBMC data²². b. UMAP shows the secondary response pseudotime calculated from the secondary response genes discovered in the fibroblast data. c. Locus zoom plot shows the COVID-19 GWAS, OAS1 and OAS3 eQTL (both in fibroblasts) associations. UMAP coordinates are identical to Extended Data Fig. 7a. d. UMAP shows the OAS3 gene expression. UMAP coordinates are identical to Fig. 2a. e. UMAP shows the eQTL effect size at rs10774671. UMAP coordinates are identical to Fig. 2a. f. Effect directions of OAS1/3 eQTLs and the risk allele of COVID-19 GWAS at the lead variant rs10774671.