Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 12;55(6):1066–1075. doi: 10.1038/s41588-023-01421-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a, Enrichment eQTLs for regulatory regions characterized by ChIP–seq for the two histone modifications (H3K27ac and H3K4me3) under two different conditions (UNST, unstimulated; PIC4h, Poly (I:C) 4-h stimulation). The error bars in the forest plot show 95% confidence intervals (standard errors) of odds ratios using N = 10,748 genes as independent samples (Methods). b, eQTL enrichment for genes with TATA-box or CGI between TSS and 100 bp upstream. The error bars in the forest plots show 95% confidence intervals (standard errors) of odds ratios using N = 10,748 genes as independent samples (Methods). c, Enrichment of lead eQTL variants for various TF motifs. The color of each point shows the average expression across all cells and the point size shows the frequency of cells with CPM > 0 for each TF gene in our fibroblast data. d, Locus zoom plot showing the RTP4 eQTL association Bayes factors. The lead eQTL variant rs62292793T>A disrupts the putative IRF1 binding motif (M1882_1.02; CIS-BP v.1.02) upstream of the RTP4 gene. e, UMAPs showing expression levels of IRF1 and RTP4. UMAP coordinates are identical to Fig. 2a. f, UMAP showing eQTL effect size of RTP4. UMAP coordinates are identical to Fig. 2a. CPM, counts per million; Prop. exp., proportion of cells the gene expressed.