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. 2023 Jun 12;55(6):1066–1075. doi: 10.1038/s41588-023-01421-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Scatter plot shows the number of colocalized eQTLs with posterior probability greater than 0.5 (y axis) against the number of independent loci where GWAS and eQTL do not share the putative causal variant (Methods). b, Heatmap shows the posterior probability of colocalization between eQTLs and GWAS loci. Only primary (colored by navy) and secondary (colored by red) response genes were shown. c, Locus zoom plots show the association of rheumatoid arthritis with hay fever, allergic rhinitis or eczema around the ETV7 gene. Points are colored by the linkage disequilibrium index (r²) with the GWAS index variant rs1008266T>C. d, UMAPs show the scaled ETV7 expression and the eQTL effect size (β) at the lead eQTL variant rs1998266T>C. Locus zoom plot shows the eQTL association for ETV7. UMAP coordinates are identical to Fig. 2a. UKBB, UK BioBank.