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. 2023 Jun 12;55(6):1066–1075. doi: 10.1038/s41588-023-01421-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — d. UMAPs of the seven different mixture components estimated from the GP mixture model (Online Methods). The values are quantile-normalised as in [0,1], and also treated as pseudotime for the first two components (primary and secondary). UMAP coordinates are identical to Fig. 2a. e. The number of genes categorised in each of the seven components. f. Top GO terms enriched with the genes detected in each of the seven DE categories.