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. 2023 Jun 5;55(6):995–1008. doi: 10.1038/s41588-023-01409-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Comparison of effect sizes and explained variance for colocalization signals for mQTLs detected for the same metabolite in both plasma and urine (N = 204; only the 99 mQTLs for which the explained variance in metabolite levels in at least one of both matrices is >3% are shown). The two inner bands represent the effect size of the mQTL in plasma (framed in red) and urine (framed in blue). Shades of orange indicate positive effect sizes, shades of aquamarine negative ones. The two outer bands represent the variance in metabolite levels in plasma and urine explained by the index SNP of the corresponding mQTL, where a darker shade of green corresponds to a greater explained variance.