Table 1.

The effect of catalyst loading, temperature and solvent in the Hantzsch reaction.

Entry	Catalyst (mg)	Time (min)	T (°C)	Solvent	Yield (%)
1	5	15	50	–	47
2	10	15	50	–	94
3	15	15	50	–	94
4	20	15	50	–	94
5	10	15	50	Toluene	25
6	10	15	50	Acetonitrile	45
7	10	15	50	Ethanol	55
8	10	15	50	H2O	70
9	10	15	r.t	–	45
10	10	15	30	–	65
11	10	15	40	–	84
12	10	15	50	–	94
13	10	15	60	–	94
14	10	15	70	–	94

Significant values are in bold.

Reaction conditions: benzaldehyde (1 mmol), dimedone (1 mmol), ethyl acetoacetate (1 mmol), ammonium acetate (1.4 mmol).