Fig. 1. KNX-002 inhibits PfMyoA.

a KNX-002 inhibits actin-activated (filled red circles, IC₅₀ = 7.2 µM, (95% CI, 5.8–9.0 µM), n = 3) and basal ATPase activity (open red circles, IC₅₀ = 3.6 µM (95% CI, 3.0–4.5 µM), n = 3). KNX-002 has little effect on the actin-activated ATPase of skeletal myosin (SkMyo2, black squares, IC₅₀ > 200 µM, n = 2) or cardiac myosin (black triangles, IC₅₀ > 100 µM, n = 2). PfMyoA data are represented as mean values ± SD. b The constituent groups of the KNX-002 structure are indicated. c The inhibition of asexual parasite blood stage growth by KNX-002 was quantified (IC₅₀ = 18.2 µM, n = 2). Source data are provided as a Source Data file.