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. 2023 Jun 12;13:9515. doi: 10.1038/s41598-023-36245-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sex-related transcriptional differences in the ipsilateral DHSC following formalin administration. (a) Illustration of the experimental design for RNA-Seq preformed on the dorsal horn of the spinal cord (DHSC) of males (n = 6) and females (n = 12, including n = 6 F1/proestrus and n = 6 F2/metestrus) following formalin injection. (b) Volcano-plot representation of the RNA-Seq identified DEG between males and females (FDR5). For a matter of representation, the following DEG were not represented on the volcano plot: Xist, Tsix, Gm2223 for females and Kdm5d, Eif2s3y, Uty, Ddx3y for males. (c) Metascape functional enrichment of transcripts enriched in males and those enriched in females. (d) IPA disease and function prediction showing clusters of male-enriched transcripts associated with immune response.