Table 2.
Comparison of child psychological problems at age 6 years between maternal preconception total homocysteine groups (PreConception Study, pregnancy phase 1992–1996; child follow-up stage 1998–2002. Reus, Spain)
| Normal tHcy (<9·04 µmol/l) | Moderately elevated tHcy (≥9·04 µmol/l) | |||||
|---|---|---|---|---|---|---|
| Child psychological problems | Mean | sd | Mean | sd | t* | P |
| CBCL/4-18 | ||||||
| Withdrawn | 55·35 | 5·24 | 57·88 | 6·23 | −1·828 | 0·072 |
| Somatic complaints | 57·16 | 6·59 | 57·83 | 7·66 | −0·393 | 0·695 |
| Anxious/depressed | 54·33 | 6·22 | 55·38 | 6·12 | −0·679 | 0·499 |
| Social problems | 53·61 | 6·50 | 53·96 | 5·52 | −0·228 | 0·820 |
| Thought problems | 53·27 | 6·34 | 54·13 | 7·80 | −0·502 | 0·617 |
| Attention problems | 55·88 | 7·51 | 56·50 | 8·94 | −0·312 | 0·756 |
| Delinquent behaviour | 55·12 | 6·87 | 56·63 | 6·76 | −0·891 | 0·376 |
| Aggressive behaviour | 54·86 | 6·46 | 57·21 | 7·90 | −1·363 | 0·177 |
| Sex problems | 54·73 | 7·10 | 55·96 | 8·76 | −0·650 | 0·518 |
| Internalizing dimension | 53·71 | 8·73 | 55·42 | 9·73 | −0·763 | 0·448 |
| Externalizing dimension | 52·80 | 8·62 | 55·79 | 9·03 | −1·379 | 0·172 |
| Total problems | 53·25 | 7·45 | 55·60 | 8·80 | −1·201 | 0·234 |
| IOWA | ||||||
| Hyperactivity | 3·21 | 2·79 | 2·88 | 3·02 | 0·475 | 0·636 |
| Aggressive behaviour | 1·42 | 1·84 | 1·67 | 2·09 | −0·513 | 0·610 |
tHcy, total homocysteine; CBCL/4-18, Child Behaviour Checklist; IOWA, Inattention-Overactivity with Aggression.
Homogeneity of variances were assumed for all the subscales.
CBCL/4-18 subscales, df=73; IOWA subscales, df=74.
*t Test: t value.