Table 3.

Significant multiple linear regression models of the effect of maternal preconception total homocysteine level on child psychological problems at age 6 years (PreConception Study, pregnancy phase 1992–1996; child follow-up stage 1998–2002. Reus, Spain)

	Unadjusted model				Adjusted model
	β	P	F (1,72)	cR 2	β	P	P	F (8,63)	cR 2
CBCL/4-18
Withdrawn		0·002	10·46	11·60			0·001	3·88	26·80
Maternal PreC tHcy	0·358				0·349	0·009
Birth weight					−0·394	0·001
Maternal anxiety					0·247	0·031
Anxious/depressed		0·066	3·48	3·30			0·000	4·50	30·80
Maternal PreC tHcy	0·216				0·303	0·019
Maternal anxiety					0·492	0·000
BMI					−0·256	0·023
Social problems		0·016	6·07	6·60			0·020	2·53	16·30
Maternal PreC tHcy	0·281				0·372	0·009
Maternal anxiety					0·280	0·022
Aggressive behaviour		0·037	4·51	4·70
Maternal PreC tHcy	0·245
Internalizing dimension		0·052	3·90	3·90			0·001	4·07	28·00
Maternal PreC tHcy	0·228				0·289	0·028
Birth weight					−0·238	0·037
BMI					−0·345	0·003
Maternal anxiety					0·421	0·000
IOWA
Aggressive behaviour		0·084	3·06	2·80			0·021	2·52	16·20
Maternal PreC tHcy	0·202				0·351	0·014
Birth weight					0·268	0·029
Parental education					−0·247	0·047

cR ², corrected R ²; PreC, preconception; tHcy, total homocysteine; CBCL/4-18, Child Behaviour Checklist; IOWA, Inattention-Overactivity with Aggression; STAI, State-Trait Anxiety Inventory; IQ, intelligence quotient; WPPSI, Wechsler Preschool and Primary Scale of Intelligence.

Adjusted models include the following covariates (enter method): birth weight (g), BMI (kg/m²) at age 6 years, parental education (combined both maternal and paternal), smoking during pregnancy, mean of anxiety during pregnancy (STAI), total IQ at age 6 years (WPPSI) and maternal tHcy at birth.