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. 2023 Mar 24;9(4):717. doi: 10.18063/ijb.717

Table 1. Summary of ML algorithms in bioprinting.

Application area Tasks ML methods Ref.
Image analysisbased in situ monitoring Identify cone mode in scaffold fabrication process in EHD jetting CNN [14]
Identify deposit fibers’ continuity, uniformity, and regularity in EBB Four-layer CNN, ResNeXt-50 network, linear SVM classifier [25]
Extract the flow pattern and droplet evolution in DBB Deep recurrent neural network (DRNN) [29]
Printing parameter optimization Predict the electrospun diameter of PCL/Gt nanofibers Multiple regression, multilayer perceptron ANN [24]
Identify suitable printing conditions for PPF scaffold in EBB Random forest classifiers (RFc), random forest regression (RFr) [26]
Optimize ink composition and printing parameters in EBB SVM classifier [27]
Predict the droplet diameter in EHD inkjet printing Statistical regression analysis, GA-NN, BPNN [28]
Optimize printing parameters for GelMA and HAMA bioinks Bayesian optimization (BO) [30]
Optimize the droplet size and printing frequency in EHD inkjet Desirability function analysis [31]
Biomaterial/bioink optimization Achieve high shape fidelity in EBB Inductive logic programming, multiple regression [32]
Achieve ideal linewidth and shape fidelity in EBB Hierarchical machine learning [33]
Predict filament diameter in EBB RFr, linear regression, intrastudy linear regression [34]
Cell performance analysis Predict cell viability SVM regression, linear regression, RFr, SVM classifier, RFc, logistic regression classifier [34]
Detect the impact of scaffold morphology on cell shape phenotypes SVM classifier [35]
Analyze cell-scaffold interaction AD-GAN [36]
Predict cell-material interactions in fibrous scaffold RFr model [37]
Associate cell morphologies with diverse microenvironment SVM classifier [38]