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. 2023 Apr 9;146(1):1–11. doi: 10.1007/s00401-023-02570-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — shows the burden of mixed pathologies in the aging brain. The bar chart on the lower left corner shows the frequencies of individual neuropathologic indices investigated in this study. The connected black dots on the x-axis indicate the specific combination of neuropathology represented (top 35 combinations shown). The histograms in the main panel show the frequencies of mixed neuropathologies, ordered by their frequency. The height of each bar corresponds to the number of persons with each combination