Table 1.
Characteristic of the study participants (N = 269)
| Age at death, years† | 91.4 (5.6) |
| FemaleΔ | 189 (70.3%) |
| Education, years† | 15.7 (3.3) |
| APOE ε4 carriersΔ | 55 (21.9%) |
| Clinical diagnosisΔ | |
| No cognitive impairment | 92 (34.2%) |
| Mild cognitive impairment | 87 (32.3%) |
| Dementia | 90 (33.5%) |
| Alzheimer’s diseaseΔ | 194 (74.1%) |
| β-amyloid load§ | 3.99 (1.03–6.35) |
| PHFtau tangle density§ | 4.96 (2.25–9.56) |
| Lewy bodiesΔ | 57 (21.5%) |
| Hippocampal sclerosisΔ | 10 (3.8%) |
| LATE-NCΔ | |
| Stage 0 | 141 (53.4%) |
| Stage 1 | 53 (20.1%) |
| Stage 2 | 19 (7.2%) |
| Stage 3 | 51 (19.3%) |
| PARTΔ | 52 (19.3%) |
| Chronic macroscopic infarctsΔ | 93 (35.5%) |
| Chronic microinfarctsΔ | 89 (34.0%) |
| Cerebral amyloid angiopathyΔ | |
| None | 48 (18.1%) |
| Mild | 144 (54.1%) |
| Moderate | 48 (18.1%) |
| Severe | 26 (9.8%) |
| AtherosclerosisΔ | |
| None | 64 (24.1%) |
| Mild | 135 (50.8%) |
| Moderate | 57 (21.4%) |
| Severe | 10 (3.8%) |
| ArteriolosclerosisΔ | |
| None | 107 (40.5%) |
| Mild | 90 (34.1%) |
| Moderate | 51 (19.3%) |
| Severe | 16 (6.1%) |
MMSE mini-mental state examination, LATE-NC Limbic predominant age-related TDP-43 encephalopathy neuropathologic changes, PART primary age-related tauopathy
†Mean (standard deviation)
ΔN (%)
§Median (interquartile range)