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. 2023 Apr 9;146(1):1–11. doi: 10.1007/s00401-023-02570-4

Table 2.

Plasma p-tau with common neuropathologies

Neuropathologies p-tau181 p-tau217
Estimate SE p Estimate SE p
β-Amyloid 0.469 0.083  < .001 0.491 0.055  < .001
Tangles 0.534 0.082  < .001 0.538 0.055  < .001
Lewy bodies 0.183 0.182 0.313 0.226 0.133 0.089
LATE-NC 0.034 0.144 0.812 0.056 0.104 0.592
Gross infarcts − 0.167 0.169 0.325 − 0.172 0.120 0.153
Microinfarcts 0.110 0.160 0.494 0.031 0.116 0.791
CAA 0.468 0.145 0.001 0.469 0.107  < .001
Atherosclerosis − 0.108 0.142 0.448 -0.001 0.102 0.989
Arteriolosclerosis 0.040 0.139 0.775 0.092 0.100 0.357

For plasma p-tau181 and p-tau217 separately, each set of statistics (Estimate, SE, and p) came from a linear or logistic regression models with each neuropathologic index as a cross-sectional outcome. All the models were controlled for age, sex and education. We did not examine the association with hippocampal sclerosis due to a small number (N = 10)